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Spleen Australia

Antibiotics

If you are living without a functioning spleen, antibiotics help reduce the risk of infection, but they do not entirely eliminate all risks.

Daily antibiotics

  • Your doctor may prescribe a daily antibiotic for extra protection against certain bacterial infections.
  • Most people take daily antibiotics for 3 years after spleen removal or being diagnosed with a poorly working spleen (hyposplenism).
  • Some people need antibiotics for longer, or even for life.

This is more likely if you:

  • Have a weakened immune system (are immunocompromised).
  • Have had a serious infection before.

Who may need lifelong antibiotics?

Some people who do not have a functioning spleen may be advised to take antibiotics lifelong.

This is usually considered for people who:

  • Have previously had a severe, life-threatening infection after losing spleen function, especially a serious pneumococcal infection.
  • Have a weakened immune system due to another medical condition, such as advanced liver disease, low antibody levels, or an organ transplant.
  • Had their spleen removed because of a blood cancer or are taking medicines that suppress the immune system.

Your doctor will assess your individual risk and discuss whether lifelong antibiotics are recommended for you.

Keep emergency antibiotics handy

  • Always keep a supply of emergency antibiotics:
  • At home
  • At work
  • When travelling

If you develop signs of infection and cannot get medical care quickly, take your emergency antibiotics and go to your nearest hospital emergency department.

Symptoms of infection could include...

Fever
Chills
Shivering
Vomiting
Diarrhoea

If you have any of the above symptoms you should see a doctor as soon as possible, or go to your nearest emergency department or call 000.

Which antibiotics will I be given?

Penicillin-based antibiotics are usually the first choice, both for your daily dose and your emergency supply.

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Penicillin allergy testing

Many people who have been told they are allergic to penicillin may not have a true allergy.

A specialist can help you find out if your penicillin allergy is real. This is called allergy de-labelling.

  • Reviews your allergy history and, if needed, perform a new allergy test
  • Confirms whether you are truly allergic to penicillin
  • May allow an incorrect allergy label to be removed from your medical record

If you have a confirmed penicillin allergy:

  • A specialist may discuss desensitisation.
  • This involves carefully giving small doses of penicillin under close medical supervision to help your body tolerate it safely.
     
If you've been told in the past that you're allergic to penicillin, it's worth seeing a specialist to check whether that's actually true.

If you do have a confirmed allergy and de-labelling isn't an option, talk to your doctor about finding a suitable alternative antibiotic. You can also reach out to Spleen Australia for extra support and guidance.

Learn more about spleen support and care:
Vaccination
Animal bites and scratches
Travel information
Care for children
Lifestyle and wellbeing